DBTMEE
Database of Transcriptome in Mouse Early Embryos


Gene Search:

DBTMEE:0018835
GeneSirt1
SynonymsSir2
Sir2alpha
Desc.sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)
LocusNM_001159589 chr10:62781753-62801783(-)
NM_019812 chr10:62781753-62801780(-)
DB links


Entrez 93759
MGI 2135607
Ensembl ENSMUSG00000020063
Vega OTTMUSG00000030914
Featureprotein-coding
GO(BP)
  •   85 Terms
      single strand break repair (GO:0000012)
      negative regulation of transcription from RNA polymerase II promoter (GO:0000122)
      chromatin silencing at rDNA (GO:0000183)
      pyrimidine dimer repair by nucleotide-excision repair (GO:0000720)
      DNA synthesis involved in DNA repair (GO:0000731)
      angiogenesis (GO:0001525)
      ovulation from ovarian follicle (GO:0001542)
      cellular glucose homeostasis (GO:0001678)
      positive regulation of protein phosphorylation (GO:0001934)
      positive regulation of adaptive immune response (GO:0002821)
      establishment of chromatin silencing (GO:0006343)
      maintenance of chromatin silencing (GO:0006344)
      transcription, DNA-dependent (GO:0006351)
      regulation of transcription, DNA-dependent (GO:0006355)
      rRNA processing (GO:0006364)
      protein deacetylation (GO:0006476)
      triglyceride mobilization (GO:0006642)
      apoptotic process (GO:0006915)
      response to DNA damage stimulus (GO:0006974)
      response to oxidative stress (GO:0006979)
      multicellular organismal development (GO:0007275)
      spermatogenesis (GO:0007283)
      regulation of mitotic cell cycle (GO:0007346)
      muscle organ development (GO:0007517)
      positive regulation of cell proliferation (GO:0008284)
      intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630)
      cellular response to starvation (GO:0009267)
      positive regulation of cholesterol efflux (GO:0010875)
      regulation of glucose metabolic process (GO:0010906)
      positive regulation of macroautophagy (GO:0016239)
      protein ubiquitination (GO:0016567)
      histone deacetylation (GO:0016575)
      peptidyl-lysine acetylation (GO:0018394)
      cell differentiation (GO:0030154)
      negative regulation of cell growth (GO:0030308)
      negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)
      negative regulation of prostaglandin biosynthetic process (GO:0031393)
      protein destabilization (GO:0031648)
      positive regulation of chromatin silencing (GO:0031937)
      negative regulation of TOR signaling cascade (GO:0032007)
      regulation of endodeoxyribonuclease activity (GO:0032071)
      negative regulation of NF-kappaB transcription factor activity (GO:0032088)
      response to insulin stimulus (GO:0032868)
      regulation of protein import into nucleus, translocation (GO:0033158)
      regulation of smooth muscle cell apoptotic process (GO:0034391)
      peptidyl-lysine deacetylation (GO:0034983)
      cellular triglyceride homeostasis (GO:0035356)
      regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)
      regulation of cell proliferation (GO:0042127)
      negative regulation of phosphorylation (GO:0042326)
      cholesterol homeostasis (GO:0042632)
      intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)
      regulation of apoptotic process (GO:0042981)
      positive regulation of apoptotic process (GO:0043065)
      negative regulation of apoptotic process (GO:0043066)
      negative regulation of I-kappaB kinase/NF-kappaB cascade (GO:0043124)
      proteasomal ubiquitin-dependent protein catabolic process (GO:0043161)
      positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280)
      negative regulation of sequence-specific DNA binding transcription factor activity (GO:0043433)
      negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)
      positive regulation of MHC class II biosynthetic process (GO:0045348)
      negative regulation of fat cell differentiation (GO:0045599)
      positive regulation of DNA repair (GO:0045739)
      negative regulation of transcription, DNA-dependent (GO:0045892)
      positive regulation of transcription from RNA polymerase II promoter (GO:0045944)
      positive regulation of insulin receptor signaling pathway (GO:0046628)
      white fat cell differentiation (GO:0050872)
      negative regulation of helicase activity (GO:0051097)
      negative regulation of protein kinase B signaling cascade (GO:0051898)
      fatty acid homeostasis (GO:0055089)
      negative regulation of androgen receptor signaling pathway (GO:0060766)
      cellular response to hydrogen peroxide (GO:0070301)
      regulation of bile acid biosynthetic process (GO:0070857)
      histone H3 deacetylation (GO:0070932)
      cellular response to tumor necrosis factor (GO:0071356)
      cellular response to hypoxia (GO:0071456)
      cellular response to ionizing radiation (GO:0071479)
      regulation of response to stress (GO:0080134)
      positive regulation of macrophage apoptotic process (GO:2000111)
      negative regulation of cAMP-dependent protein kinase activity (GO:2000480)
      positive regulation of cAMP-dependent protein kinase activity (GO:2000481)
      negative regulation of cellular response to testosterone stimulus (GO:2000655)
      negative regulation of peptidyl-lysine acetylation (GO:2000757)
      negative regulation of cellular senescence (GO:2000773)
      positive regulation of cellular senescence (GO:2000774)
GO(MF)
GO(CC)
Ver2_FPKM
DBTMEEGeneRefSeqEntrezSPR_FPKMOo_FPKM1C_FPKM2C_FPKM4C_FPKMESC_FPKMMEF_FPKMp1C_FPKMp4C_FPKMiPSC_FPKM
2019375
(v2.0)
Sirt1NM_001159589,NM_01981293759
2.614917.234127.1537105.388103.94118.46998.2551817.7596101.37117.8308
SOLiD_Cluster_gene_guided
DBTMEEGeneEntrezClusterCorrelation
0018835
(v1.0)
Sirt193759
Major ZGA0.99333
SPR_Histone_Erkek_+-5KfromTSS
DBTMEEGeneEntrezH3.3_1
(ChIP/Input)
H3.3_1
(Enrich; log2)
H3.3_2
(ChIP/Input)
H3.3_2
(Enrich; log2)
H3K4me3_1
(ChIP/Input)
H3K4me3_1
(Enrich; log2)
H3K4me3_2
(ChIP/Input)
H3K4me3_2
(Enrich; log2)
H3K27me3_1
(ChIP/Input)
H3K27me3_1
(Enrich; log2)
H3K27me3_2
(ChIP/Input)
H3K27me3_2
(Enrich; log2)
2019375
(v2.0)
Sirt193759
672/3780.3165439/3780.0994180/3782.4931463/3781.617539/378-1.1983313/378-0.8684
SPR_Histone_Erkek_+-2KfromTSS
DBTMEEGeneEntrezH3.3_1
(ChIP/Input)
H3.3_1
(Enrich; log2)
H3.3_2
(ChIP/Input)
H3.3_2
(Enrich; log2)
H3K4me3_1
(ChIP/Input)
H3K4me3_1
(Enrich; log2)
H3K4me3_2
(ChIP/Input)
H3K4me3_2
(Enrich; log2)
H3K27me3_1
(ChIP/Input)
H3K27me3_1
(Enrich; log2)
H3K27me3_2
(ChIP/Input)
H3K27me3_2
(Enrich; log2)
2019375
(v2.0)
Sirt193759
339/1540.6223199/1540.2521161/1543.5647402/1542.695814/154-1.3406111/154-1.0615
SPR_Methy_Kobayashi_+-5KfromTSS
DBTMEEGeneEntrezTotal_mC_levelsNumber_of_mCsAveraged_Methylation_level(%)
2019375
(v2.0)
Sirt193759
54.924413740.09
SPR_Methy_Kobayashi_+-2KfromTSS
DBTMEEGeneEntrezTotal_mC_levelsNumber_of_mCsAveraged_Methylation_level(%)
2019375
(v2.0)
Sirt193759
15.74189516.57
SOLiD_Oo-4C_FPKM_gene_guided
DBTMEEGeneRefSeqEntrezOo_FPKM1C_FPKM2C_FPKM4C_FPKMMEF_FPKM
0018835
(v1.0)
Sirt1NM_001159589,NM_001159590,NM_01981293759
19.816120.770387.747981.03436.53106
SOLiD_NMNR_Oo-4C_FPKM_gene_guided
DBTMEEGeneRefSeqEntrezOo_FPKM1C_FPKM2C_FPKM4C_FPKMMEF_FPKM
0018835
(v1.0)
Sirt1NM_001159589,NM_001159590,NM_01981293759
24.59123.0348101.05795.25737.69528
SOLiD_Illumina_Oo-1C-Sperm_FPKM_gene_guided
DBTMEEGeneRefSeqEntrezOo_FPKMSPR_FPKM1C_FPKM
0018835
(v1.0)
Sirt1NM_001159589,NM_001159590,NM_01981293759
20.71950.95560222.6608
SOLiD_Partheno1C_FPKM_gene_guided
DBTMEEGeneRefSeqEntrezOo_FPKM1C_FPKMp1C_FPKM
0018835
(v1.0)
Sirt1NM_001159589,NM_001159590,NM_01981293759
20.224320.561713.8223
SOLiD_NMNR_Partheno1C_FPKM_gene_guided
DBTMEEGeneRefSeqEntrez1C_FPKMp1C_FPKM
0018835
(v1.0)
Sirt1NM_001159589,NM_001159590,NM_01981293759
23.393415.7885
SOLiD_Illumina_Oo-p1C-Sperm_FPKM_gene_guided
DBTMEEGeneRefSeqEntrezOo_FPKMSPR_FPKMp1C_FPKM
0018835
(v1.0)
Sirt1NM_001159589,NM_001159590,NM_01981293759
20.73160.94251615.1598
SOLiD_Partheno4C_FPKM_gene_guided
DBTMEEGeneRefSeqEntrez2C_FPKM4C_FPKMp4C_FPKM
0018835
(v1.0)
Sirt1NM_001159589,NM_001159590,NM_01981293759
81.240978.241978.6738
SOLiD_NMNR_Partheno4C_FPKM_gene_guided
DBTMEEGeneRefSeqEntrez4C_FPKMp4C_FPKM
0018835
(v1.0)
Sirt1NM_001159589,NM_001159590,NM_01981293759
94.228494.9443
Illumina_Oo-2C_FPKM_gene_guided
DBTMEEGeneRefSeqEntrezOo_FPKM2C_FPKM
0018835
(v1.0)
Sirt1NM_001159589,NM_001159590,NM_01981293759
21.250698.575
SOLiD_SC_Oo_REPLICA_FPKM_gene_guided
DBTMEEGeneRefSeqEntrezOo_1_1Oo_2_1
0018835
(v1.0)
Sirt1NM_001159589,NM_001159590,NM_01981293759
4.109555.30943
NIA60mer
DBTMEEArray Feature NumberOligo Parent CloneUnigeneGeneEntrezU_ClusterNAP_ClusterGene_U/NAPTIGRSwissProtESTOo1C2C4C8CMorulaBlastocyst
0018835
(v1.0)
5231AI322487.1Mm.12604Sirt193759
Sirt13.113.01563.30693.2133.12223.15393.0678
0018835
(v1.0)
11579H3119B12-3Mm.12604Sirt193759
U031873NAP009257-001Sirt1;TC893548Q923E4U,F,23.36463.20453.25913.61313.51863.28833.3783
MOE430
DBTMEEProbe_IDUnigeneGeneRefSeqEntrezOo1C2C8CBlastocyst
0018835
(v1.0)
1418640_atMm.351459Sirt1NM_019812.2,NM_001159589.1,NM_001159590.193759
225.45297.775942.075577.425208.75
Agilent44K
DBTMEEProbe_IDGeneAcc.EntrezOo1_x-foldOo1_p-value (t-test)Oo1_FlagOo2_x-foldOo2_p-value (t-test)Oo2_Flag
0018835
(v1.0)
A_51_P141152Sirt1NM_01981293759
11P0.570.124P
Proteome N/A